T O P
AutoModerator

**Please read before commenting or asking a question:** This is a very strict science sub. No linking news sources (Guardian, SCMP, NYT, WSJ, etc.). Questions and comments in this thread should pertain to research surrounding SARS-CoV-2 and its associated disease, COVID-19. Do not post questions that include personal info/anecdotes, asking when things will "get back to normal," or "where can I get my vaccine" (that is for r/Coronavirus)! If you have mask questions, please visit r/Masks4All. Please make sure to read our rules carefully before asking/answering a question as failure to do so may result in a ban. **If you talk about you, your mom, your friend's, etc., experience with COVID/COVID symptoms or vaccine experiences, or any info that pertains to you or their situation, you will be banned.** *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/COVID19) if you have any questions or concerns.*


[deleted]

[удалено]


AutoModerator

Your comment has been removed because * **Off topic and political discussion is not allowed.** This subreddit is intended for discussing science around the virus and outbreak. Political discussion is better suited for a subreddit such as /r/worldnews or /r/politics. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/COVID19) if you have any questions or concerns.*


BJsInMyPJs

Are contraction rates about to surge in the US?


jdorje

Unknown and could be regional. BQ.1 is the variant that would cause a surge, and it's right about now passed 50% of cases. Earlier on it was doubling weekly. But its rate of growth has dropped steadily over the last few months, likely tied to bivalent vaccination. What it will peak at is not easily predictable. Sources: * [cov-spectrum](https://cov-spectrum.org/explore/United%20States/AllSamples/Past6M/variants?nextcladePangoLineage=bq.1*&) * [b lab](https://github.com/blab/rt-from-frequency-dynamics/tree/master/results/omicron-countries-split), 11 days old now though


Priest_of_Gix

Is it true that we've seen atigenic imprinting with the vaccines? If so, isn't there a risk associated with not updating the primary vaccine schedule to reflect newer variants (rather than just boosters)? For example, an unvaccinated and infection-naive child or someone who didn't have access until now, would they be actually setting themselves up worse in the long run to get a primary schedule based on wild type? Whereas if primary exposure is from a current variant then vaccination would promote the production of antibodies closer to upcoming variants? Not sure if I worded this properly but I hope the point comes across


jdorje

> Is it true that we've seen atigenic imprinting with the vaccines? Research on imprinting is tremendously uncertain, even conflicting. There is moderate evidence that the first omicron infection/vaccine dose after an original-strain infection/vaccine dose generates a narrow response. There is also strong evidence though that your antibodies against similar variants are stronger on breakthroughs than on naive infections. > If so, isn't there a risk associated with not updating the primary vaccine schedule to reflect newer variants For health departments, there is zero reason to not update the primary sequence (for kids mostly) to be multivalent/megavalent. But there's no evidence that there is any "risk" to getting an original-strain vaccination even while the original strain is gone. This *in particular* applies to the first dose, which is responsible for most of the T cell generation - and T cells are not susceptible to imprinting (there is strong evidence supporting this).


farrapona

How effective are masks? I'm considering wearing one to the store, but would be nice to know how effective they are. Has a study ever been conducted to tell us this? You take 3 'dummies', have a ventilator or whatever suck air through the dummies mouth while moving around a populated enclosed space like a big box store or mall. You have an unmasked dummy, a paper masked dummy and a KN95 masked dummy. Then just measure what they 'inhaled'. Can you find traces of covid or some other substance with similar physical properties that can act as a proxy - then compare the levels of absorption between unmasked and masked? Really what i am looking for is the level of prevention one gets from wearing a mask, not just 'mask is better than no mask'


jdorje

https://www.pnas.org/doi/10.1073/pnas.2110117118 Fitted n95s/ffp2's are extremely effective. Fitted means that all the air should go through the mask, not around it. Cloth and surgical masks are significantly less effective.


EnderWiII

I heard the booster doesn't protect against the latest variants?


jdorje

That isn't supported by the theory or the research. We do not have good research on the single bivalent booster. Nearly all of the available research is small-scale immunogenicity studies. These have given directly conflicting results, from "no better than original vaccines" to "amazingly good and should end the omicron pandemic very quickly". One thing they are very consistent on though is that the booster generates very high antibody titers in those with previous omicron infection, but not so much in those who haven't been exposed to omicron before. Real-world data here is useless, because it is impossible to control for the cohort difference between those who get the booster and those who don't - to over-simplify, if everyone who had caught omicron declined it and everyone who hadn't caught omicron took the dose, we would expect more infections among the booster group. The theory says it should be very effective, though not necessarily after a single dose in those with no prior infection. BQ.1.1 only has 3 RBD mutations from BA.5, 2 of which are very significant to immune escape. The end result (in the immunogenicity studies that are too small-scale to really be relied on) is about a 5-fold reduction in neutralization, same as we had from original vaccines to delta and beta. And we had extremely good protection from those after 2-3 doses (or previous infection with one dose). Despite the infuriating lack of research, there remains no reason to believe that an omicron vaccine will work any differently or worse against the omicron strain than the original vaccine worked against the original/unnamed strain. Editorial: if it's been more than 90 days since your last infection, you should get the booster asap.


hatsilim

Regarding this study - [https://www.reddit.com/r/COVID19/comments/z1owzm/enhanced\_replication\_of\_sarscov2\_omicron\_ba2\_in/](https://www.reddit.com/r/COVID19/comments/z1owzm/enhanced_replication_of_sarscov2_omicron_ba2_in/) ​ Is anyone aware of observational studies that look at BA.2/4/5 neuro effects and how/whether this enhanced replication manifests in whole human brains vs. organoids?


NotsogoodyBag

Is there any role for low dose oral dexamethasone or other oral steroid like methylprednisone for MILD Covid? Most of the research usually discuss IV steroid for severe covid. Oral steroid here as in just to help relieving the sore throat